Figure 4. Regeneration in the absence of protein synthesis.

(A) Direct model of coordination, in which the regeneration-triggering stimulus directly triggers each gene. (B) Cascade model, in which regeneration-triggering stimulus drives one gene, whose product then drives another gene, with potentially multiple steps being required to ultimately trigger all genes in the cascade. (C) Heatmap showing OA-specific genes whose expression pattern in cycloheximide cells is highly correlated with the expression pattern in untreated cells. (D) Heatmap showing OA-specific genes whose expression pattern in cycloheximide cells is uncorrelated with the expression pattern in untreated cells.