Table 2.
RESPOND parameters.
| Parameter | Baseline Value | Range | Source |
|---|---|---|---|
| Population Demographics and epidemiology | |||
| Proportion male | 0.58 | (43) | |
| Mean age, y | 47 | (43) | |
| Proportion in detox at baseline | 0.013 | (34) | |
| Proportion on MOUD at baseline | 0.16 | (43) | |
| Proportion with injection drug use at baseline | 0.25 | (54) | |
| Proportion actively using at baseline | 0.84 | (55, 56) | |
| Incidence of OUD, annual avg number of people | 17,950 | Range: 8,164-44,564 | (43) |
| Standardized mortality ratio for drug use | |||
| Injection drug users | 5.1 | 4.4-5.7 | 2010 Census, (43) |
| Non-injection drug users | 2.1 | 1.8-2.3 | 2010 Census, (43) |
| Movement into detox, monthly rate per 1000 people | 16.7 | 6.0-30.7 | (34) |
| Movement onto MOUD treatment, monthly rate per 1000 people | |||
| Buprenorphine | 21.1 | 11.4-41.8 | (43) |
| Methadone | 4.5 | 2.4-24.4 | (43) |
| Naltrexone 1 | 2.2 | 0.7-21.5 | (43) |
| Proportion retained on MOUD treatment at, 6-months | |||
| Buprenorphine | 0.34 | 0.17-0.51 | (7) |
| Methadone | 0.56 | 0.28-0.84 | (33) |
| Naltrexone 1 | 0.21 | 0.11-0.32 | (7) |
| Overdose monthly rate per 1,000 people | |||
| No treatment | 1.6 | 1.5-2.8 | (43) |
| Buprenorphine | 0.6 | 0.6-1.1 | (31) |
| Naltrexone 1 | 1.3 | 1.2-2.3 | (31) |
| Methadone | 1.2 | 1.1-2.1 | (32) |
| Post-treatment | 3.1 | 2.9-5.4 | |
| Fatal overdose proportion | 0.14 | 0.13-0.15 | (43) |
| Costs (Healthcare Sector) | |||
| Treatment Costs, Weekly (Visit and Medication costs) | |||
| Detox, no MOUD | $3,057 | $805-$8,204 | (37, 38) |
| Detox, with buprenorphine (16mg daily) | $3,259 | $1,007-$8,406 | (37, 38) |
| Detox, with methadone (80mg daily) | $3,215 | $963-$8,362 | (37, 38) |
| Detox, with naltrexone (Vivitrol injection, one monthly) | $4,421 | $2,169-$9568 | (37, 38) |
| Buprenorphine (16mg daily) | $114 | $75-$163 | Expert Opinion, Federal Supply Schedule |
| Methadone (80mg daily) | $126 | $116-$136 | https://www.drugabuse.gov/publications/research-reports/medications-to-treat-opioid-addiction/how-much-does-opioid-treatment-cost |
| Naltrexone (Vivitrol injection, one monthly) | $327 | $316-$338 | Expert Opinion, Federal Supply Schedule |
| Overdose costs 1 | |||
| Fatal overdose cost | $886 | $443-$1329 | (57, 58) |
| Non-fatal overdose cost | $4,557 | $2,279-$6,836 | (57, 58) |
1.
Injectable naltrexone (Vivitrol).
2.
Overdose costs include ambulance costs, emergency room costs, and inpatient costs.
3.
MOUD: medications for opioid use disorder
4.
OUD: opioid use disorder