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Effect of compounds from each hit series on total and progressive motility determined by CASA. Increasing concentrations of compounds were incubated for 4 h with human sperm after which time total (solid fill) and progressive (dotted fill) were measured. Data are plotted as a percent of total sperm population and are the mean±SEM of at least 3 individual experiments. **p <0.005, ***p <0.0005 and ****p <0.0001.
