ABSTRACT
To inform public health policy, it is critical to monitor COVID-19 vaccine effectiveness (VE), including against acquiring infection. We estimated VE using self-reported vaccination in a retrospective cohort of repeat blood donors who donated during the first half of 2021, demonstrating a viable approach for monitoring of VE via serological surveillance. Using Poisson regression, we estimated an overall VE of 88.8% (95% CI: 86.2–91.1), adjusted for demographic covariates and variable baseline risk. Time since first reporting vaccination, age, race-ethnicity, region, and calendar time were statistically significant predictors of incident infection.
Keywords: COVID-19, SARS-CoV-2, vaccines, vaccine effectiveness, blood donors
Contributor Information
Eduard Grebe, Vitalant Research Institute, San Francisco, CA, USA; University of California San Francisco, San Francisco, CA, USA; South African DSI-NRF Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA), Stellenbosch University, Stellenbosch, South Africa.
Elaine A Yu, Vitalant Research Institute, San Francisco, CA, USA.
Marjorie D Bravo, Corporate Medical Affairs, Vitalant, Scottsdale, AZ, USA.
Alex Welte, South African DSI-NRF Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA), Stellenbosch University, Stellenbosch, South Africa.
Roberta L Bruhn, Vitalant Research Institute, San Francisco, CA, USA; University of California San Francisco, San Francisco, CA, USA.
Mars Stone, Vitalant Research Institute, San Francisco, CA, USA; University of California San Francisco, San Francisco, CA, USA.
Valerie Green, Creative Testing Solutions, Tempe, AZ, USA.
Phillip C Williamson, Creative Testing Solutions, Tempe, AZ, USA.
Leora R Feldstein, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jefferson M Jones, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Michael P Busch, Vitalant Research Institute, San Francisco, CA, USA; University of California San Francisco, San Francisco, CA, USA.
Brian Custer, Vitalant Research Institute, San Francisco, CA, USA; University of California San Francisco, San Francisco, CA, USA.
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