Figure 2. Metastability and time-resolved functional networks in disorders of consciousness (DoC).

(A) Metastability for all groups: healthy controls (HC), minimally conscious state (MCS), and unresponsive wakefulness state (UWS) patients. (B–H) Distributions of nonstationarity (excursions from the median) for the residuals and time-resolved networks. (I–N) Spatial patterns of time-resolved output networks. Abbreviations: DMN, default mode network; FPN, frontoparietal network; Sub-FTPN, subcortical fronto-temporoparietal network. *, ** and *** denote p < 0.05, p < 0.01 and p < 0.001, respectively (Mann–Whitney U tests). The colourbar indicates the strength of that specific area to the overall spatial pattern. Note, the Sub-FTPN appears as modified network from the initially assigned subcortical network. This Sub-FTPN consists of the following brain regions: bilateral thalamus, caudate, right putamen, bilateral anterior and middle cingulate, inferior and middle frontal areas, supplementary motor cortex, middle and inferior temporal gyrus, right superior temporal, bilateral inferior parietal, and supramarginal gyrus.

Figure 2—figure supplement 1. Dwell time of time-resolved functional networks in disorders of consciousness (DoC).

(A–G) Dwell time for all the networks for the three groups (healthy control [HC], minimally conscious state [MCS], and unresponsive wakefulness syndrome [UWS]). Dwell times for all states add up to one. Abbreviations: DMN, default mode network; FPN, frontoparietal network. *, ** and *** denote p < 0.05, p < 0.01 and p < 0.001, respectively.