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. 2022 Jun 30;608(7923):618–625. doi: 10.1038/s41586-022-05009-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, MIWI piRISC target cleavage assay in the presence of lysates from different animals. T.ni: Trichoplusia ni. Macaque: rhesus macaque. A digital overexposure is shown below the gel. b, Representative target cleavage assay using the indicated PIWI protein in the presence of different GTSF1 orthologs (100 nM). Numbers below the gel lanes report fraction target cleaved (mean ± SD; n = 3). c, Left: Percent identity of different GTSF1 orthologs Right: Unrooted tree of GTSF1 orthologs. For gel source data, see Supplementary Fig. 1.