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. 2022 Jan 31;18(9):2216–2228. doi: 10.1080/15548627.2022.2025571

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 7. — HDM-challenged atg5^−/− obese mice develop TSLP-dependent and IL33-dependent asthma. (A) Experimental timeline. atg5^−/− obese mice and WT obese mice were immunized as described in Figure 1A. Anti-thymic stromal lymphoprotein (TSLP) antibody (20 μg), anti-IL33 antibody (6 μg), or isotype controls were intranasally administered before HDM challenges. (A and D) Lung resistance (R_L), (B and E) Differential cell counts in BALF. TCC, total cell count; MAC, macrophages; Ly, lymphocytes; Eo, eosinophils; Neut, neutrophils. (C and F) Hematoxylin and eosin-staining. Original magnification: 100 × . (E) PAS staining. Data are representative of two independent experiments (n = 5–7/group). Data are expressed as the mean ± SEM. P-values were calculated using two-way ANOVA test post hoc test with the Tukey’s multiple comparison test. *, P < 0.05, **, P < 0.01, ***, P < 0.001.