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. 2022 May 26;49(11):3956–3957. doi: 10.1007/s00259-022-05845-2

Correction to: In vitro dose effect relationships of actinium‑225‑ and lutetium‑177‑labeled PSMA‑I&T

Eline A M Ruigrok 1,2, Giulia Tamborino 1,3, Erik de Blois 1, Stefan J Roobol 1,4, Nicole Verkaik 4, Marijke De Saint-Hubert 3, Mark W Konijnenberg 1, Wytske M van Weerden 2, Marion de Jong 1, Julie Nonnekens 1,4,
PMCID: PMC9399007  PMID: 35614268

Correction to: European Journal of Nuclear Medicine and Molecular Imaging

10.1007/s00259-022-05821-w

The publisher regrets that the Tables 2 and 3 that appear in the original article are incorrect. The correct tables appear below.

Table 2.

Self-absorbed dose rates to the nucleus per unit activity (Gy(Bq*s)-1) depending on radionuclide localization (i.e. cell membrane and cytoplasm) and cellular dimension (i.e. minimum, average and maximum)

Floating set-up (spherical cells)
Dimension Source compartment
Cell membrane Cytoplasm
Lutetium-177 Actinium-225 Lutetium-177 Actinium-225
Minimum 2.02E-04 1.05E-01 3.67E-04 1.78E-01
Average 1.04E-04 5.63E-02 1.98E-04 1.01E-01
Maximum 6.40E-05 3.56E-02 1.23E-04 6.48E-02
Attached cells set-up (ellipsoidal shape)
Dimension Source compartment
Cell membrane Cytoplasm
Lutetium-177 Actinium-225 Lutetium-177 Actinium-225
Minimum 3.43E-04 1.61E-01 2.14E-04 1.09E-01
Average 1.65E-04 8.31E-02 1.16E-04 6.15E-02
Maximum 7.66E-05 4.05E-02 5.89E-05 3.23E-02
Contribution of the radioactive medium
Lutetium-177 Actinium-225
2.30E-11 4.57E-09

Table 3.

Absorbed dose (Gy) accumulated over 7 days (i.e. duration of clonogenic survival assay) of either [177Lu]Lu-PSMA-I&T or [225Ac]Ac-PSMA-I&T treatment. The absorbed dose is reported for 3 cellular dimension assumptions (i.e. average, minimum and maximum) in order to provide the average and maximum range of variation of the absorbed dose calculations

[177Lu]Lu-PSMA-I&T
Dimension
Concentration (MBq/mL) Average Minimum Maximum
0 0 0 0
0.1 0.74 1.48 0.37
0.2 1.48 2.96 0.74
0.3 2.22 4.43 1.11
0.4 2.96 5.91 1.48
0.5 3.70 7.39 1.85
[225Ac]Ac-PSMA-I&T
Dimension
Concentration (kBq/mL) Average Minimum Maximum
0 0 0 0
0.037 0.08 0.16 0.04
0.1 0.22 0.42 0.11
0.185 0.41 0.78 0.21
0.25 0.56 1.05 0.29
0.37 0.83 1.55 0.42
0.5 1.12 2.10 0.57
0.75 1.67 3.15 0.86

The original article has been corrected.

Footnotes

This article is part of the Topical Collection on Erratum.

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