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. 2022 Aug 10;608(7924):724–732. doi: 10.1038/s41586-022-05072-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a,b, SNV (a) and structural variation (SV) burden (b) by normal cell type or malignancy. The box shows the interquartile range and the centre line shows the median. Whiskers extend to the minimum of either the range or 1.5× the interquartile range. Normal lymphocytes (magenta) exclude paediatric samples. AML, acute myeloid leukaemia; CLL, chronic lymphocytic leukaemia; Cut, cutaneous; DLBC, diffuse large B cell. c, The proportion of mutational signatures per genome. For each genome, signatures with a 90% confidence interval lower bound of less than 1% are excluded. Normal lymphocytes (labelled in magenta) are from donor AX001. T_reg, T regulatory cells. d,e, SBS9 burden (d) and proportion (e) by cell type or malignancy. The box shows the interquartile range and the centre line shows the median. Whiskers extend to the minimum of either the range or 1.5× the interquartile range. f,g, Heat map showing the level of enrichment of SBS9 (f) and SHM (g) signatures near frequently mutated genes for that signature compared with the whole genome. Number of structural variants per group: B cell: 145, T cell: 841, ALL: 523, Burkitt lymphoma: 305, CLL mutated: 252, CLL unmutated: 440, cutaneous T cell lymphoma: 204, DLBC lymphoma: 3,754, follicular lymphoma: 1,095. a,b,d,e, Number of genomes per group: naive B: 68, memory B: 68, naive T: 332, memory T: 87, Burkitt lymphoma: 17, CLL mutated: 38, CLL unmutated: 45, cutaneous T cell lymphoma: 5, DLBC lymphoma: 47, follicular lymphoma: 36, multiple myeloma: 30, myeloid–AML: 10.