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. 2022 Aug 1;10(8):1853. doi: 10.3390/biomedicines10081853

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of repeated CBD exposure on BDNF-downstream signaling in the striatum. Rats were treated with repeated injections of 30 mg/kg for seven days and killed twenty-four hours after the last treatment. Protein levels of phospho(p)-AktS473 (a), Akt (b), pAkt/Akt (c), pERK2T185-Y187 (d), ERK2 (e), and pERK2/ERK2 (f) measured in the homogenate of the striatum are expressed as percentages of saline-treated rats. Below the graphs, representative immunoblots are shown for pAktS473 (60 kDa), Akt (60 kDa), pERK2T185-Y187 (42 kDa), ERK2 (42 kDa), and β-Actin (43 kDa) proteins. Bar graphs represent the mean ± SEM from eight independent determinations for each experimental group. Unpaired Student’s t-test. *** p < 0.001 vs. saline-treated rats. Saline n = 8, CBD 30 mg/kg n = 8.