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Effects of chronic CBD (60 mg/kg body weight) treatment on the hippocampal reorganization induced by PTZ-kindling in rats. (a) Mean thickness of the pyramidal cell layer; (b) the density of GFAP-positive astrocytes; (c) the density of IBA1-positive microglia; (d) the density of neuronal debris, defined as NeuN-positive fragments surrounded by astrocytes. Data are expressed as mean ± SEM (n = 5–8).; CBD, cannabidiol; * p < 0.05; ** p < 0.01.
