Table 1.
Cannabidiol concentrations in plasma and brain at Cmax and Cmin after the oral administration of 60 mg/kg body weight.
| CBD Concentrations | Rat # | Plasma Concentration (ng/mL) | Brain Concentration (ng/g) | Brain-to-Plasma Ratio |
|---|---|---|---|---|
| 1 h after administration | 1 | 259.93 | 1058.50 | 4.072 |
| 2 | 6326.57 | 16,886.61 | 2.669 | |
| 3 | 800.39 | 1475.58 | 1.844 | |
| 4 | 198.69 | 642.07 | 3.232 | |
| 5 | 2295.02 | 2455.34 | 1.070 | |
| Mean | 1976.12 | 5260.6 | 2.577 | |
| SEM | 1151.41 | 3284.0 | 0.524 | |
| 24 h after administration | 6 | 23.20 | 111.08 | 4.788 |
| 7 | 26.20 | 79.98 | 3.053 | |
| 8 | 28.67 | 105.28 | 3.672 | |
| 9 | 22.50 | - * | - | |
| 10 | 20.40 | 69.35 | 3.400 | |
| Mean | 24.19 | 91.4 | 3.728 | |
| SEM | 3.25 | 20.0 | 0.336 |
* As a result of inadequate tissue perfusion, the brain tissue sample was excluded from analysis. # Data points are labeled by rat number.