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. 2022 Aug 4;10(8):449. doi: 10.3390/toxics10080449

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Workflow of the developed procedure to identify PFAS-mediated metabolic-related events. The proposed strategy is a multistep procedure: (1) Input: two lists (one with PFAS compounds and one with biological events (MIE, KE, and AO)) are needed as input data. (2) The AOP-helpFinder tool first extracts all available PubMed abstracts mentioning at least one PFAS from the first list. Then the tool retrieves biological events from the second list that are present in the selected abstracts and computes a distance score based on text mining and graph theory methods for prioritization. (3) As results, a linkage is proposed to help build AOPs induced by PFAS and related to metabolic outcomes.