Table 3.
The diagnostic power of different metabolite biomarkers in differentiating T2DM from Health controls or DKD from T2DM.
| Metabolites | Pathway and Sub-Pathway | AUC (95% CI) | |
|---|---|---|---|
| Health vs. T2DM | T2DM vs. DKD | ||
| N-acetylaspartic acid | Alanine, aspartate and glutamate metabolism | 0.777 (0.655, 0.898) | 0.739 (0.612, 0.866) |
| L-valine | Valine, leucine and isoleucine degradation | 0.943 (0.889, 0.997) | 0.834 (0.733, 0.936) |
| Betaine | Glycine, serine and threonine metabolism | 0.863 (0.766, 0.960) | 0.834 (0.732, 0.937) |
| Isoleucine | Valine, leucine and isoleucine degradation | 0.951 (0.905, 0.997) | 0.932 (0.869, 0.995) |
| Asparagine | Alanine, aspartate and glutamate metabolism | 0.942 (0.889, 0.995) | 0.809 (0.698, 0.920) |
| L-methionine | Cysteine and methionine metabolism | 0.852 (0.754, 0.950) | 0.753 (0.628, 0.878) |