Table 7.

Descriptive characteristics of included interventional/observational lice studies (n = 5).

	Study Design	Study Participants	Intervention Description	Outcome Measure(s)	Treatment Outcome(s)	Quality Score
Barker and Altman, 2010 [110], Australia	Randomised assessor-blind controlled trial	Individuals with headlice (n = 132, Age range: 4–12 years)	Test group I (n = 43): Received TTO (10% w/v) and lavender oil (LO, 1% w/v) (TTO/LO, NeutraLice®) lotion applied three times on Days 1, 7, and 14 Test group II (n = 45): Received Suffocation product (Benzyl alcohol, NeutraLice Advance®) applied three times on Days 1, 7, and 14 Control (n = 44): Received Pyrethrins (1.65 mg/g) and Piperonyl butoxide (16.5 mg/g) (P/PB, Banlice Mousse® product) applied twice on Days 0 and 7	Cure rate (% of louse free participants) at Day 15 (test products) and Day 8 (Control) (AEs) occurrence	Cure rate: 95.4% (41/43) in TTO/LO group vs. 88.9% (40/45) in suffocation group vs. 22.7% (10/44) in Control group (p < 0.0001) AEs: 25 individuals with mild (n = 22) and moderate (n = 3) AEs) (n = 13 or 30.2% with stinging, n = 8 or 18.6% with flaky scalp/dry scalp and n = 4 or 9.3% with erythema among these, n = 3 moderate AEs (n = 1, stinging of the eyes; n = 1, stinging of the neck; and n = 1, skin erythema) in TTO/LO group vs. 3 (6.7%) individuals with mild AEs (flaky scalp/dry scalp) in Suffocation group vs. 4 (6.8%) individuals with mild AEs (flaky scalp/dry scalp and erythema, 1 subject (2.3%) in P/PB group	5 (High)
Barker and Altman, 2011 [111], Australia	Ex vivo Randomised assessor-blind controlled trial (ovicidal study)	Individuals with headlice (n = 92, Age range: 4–12 years)	Test group I (n = 31): Received TTO (10% w/v) and LO (1% w/v) (TTO/LO, NeutraLice®) lotion applied once on Day 1 Test group II (n = 31): Received Suffocation product (Benzyl alcohol, NeutraLice Advance®) applied once on Day 1 Control (n = 30): Received eucalyptus oil (11% w/w) and lemon tea tree oil (1% w/w) pediculicide (EO/LTTO, MOOV®) applied once on Day 1	Ovicidal rate (Per cent ovicidal efficacy) after 14 days AEs occurrence	Ovicidal rate (%) (SD): 44.4% (23%) in TTO/LO group vs. 68.3% (38%) in Suffocation group vs. 3.3% (16%) in EO/LTTO group (p < 0.0001) Aes: 4 (12.9%) individuals with mild Aes (n = 3 stinging and n = 1 redness) in TTO/LO group vs. 0% in Suffocation group vs. 6 (20%) individuals with mild Aes (n = 2 stinging and n = 4 redness) in EO/LTTO group	5 (High)
McCage et al., 2002 [103], USA	Cohort study	Individuals with headlice (n = 16, Age: not reported)	Test (n = 16): Received a shampoo formulation (containing 0.5% TTO, 1.0% thymol and 0.5% Paw Paw extract) applied three times eight days apart Control: None	Cure rate	Cure rate: 100% (16/16) (no p-value is reported)	6 (Medium)
Novelo, 2015 [105], USA (Patents)	Case study	Individuals with body lice (n = 1, Age: not reported)	Test (n = 1): Received a body wash (3.7 mL) containing TTO (6%), Cinnamon oil (8%), Oregano oil (14%), Lavender oil (40%), Peppermint oil (10%), Citronella oil (5%), Orange oil (7%), and Rosemary oil (6%) daily for two days Control: None	Cure rate	Cure rate: 100% (1/1)	3 (Low)
Whitledge, 2002 [106], USA	Case study	An individual with headlice (n = 1, Age: 8 years)	Test (n = 1): Received a shampoo containing TTO (9%), Anise oil (7%), Lemon oil (4%), SD alcohol (50%), water (28%), and fragrance (2%) applied once for 10–15 min Control: None	Cure rate AEs occurrence	Cure rate:100% (1/1) AEs: No reports of sensitivity or adverse reactions	7 (High)