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. 2022 Oct 13;185(21):4008–4022.e14. doi: 10.1016/j.cell.2022.08.024

Figure 6.

Figure 6

Determining antibody robustness to synthetic RBD variants and mutational lineages

(A) Omicron (BA.1) mutations covered by combinatorial library RBM-2.

(B) Binding prediction for single and combinatorial mutations observed in Omicron.

(C) Dynamic escape profile along Omicron lineage with percentage escape sequences across all mutations at distance 1–4 from Wu-Hu-1.

(D) Antibody prediction of ACE2 binding RBDs for each antibody at edit distance 6–10 from Wu-Hu-1 (10,000 sequences simulated in triplicate, only confident predictions shown (i.e., P(ACE2 binding) > 0.5 and either P(antibody binding) > 0.75 or P(antibody escape) < 0.25 for both RNN and RF).

(E) Total count of confident predictions across all distances (mean across triplicates).