Figure 3. Spike time tiling coefficient (STTC) decreases throughout development with a specific spatial profile in the mouse medial prefrontal cortex (mPFC).

(A) Schematic representation of the STTC quantification. (B) Multivariate linear regression coefficients with respect to STTC lag (n=40,921 spike train pairs and 82 mice). (C) Average STTC at 1 s lag of P4, P6, P8, P10, and P12 mice over distance (n=40,921 spike train pairs and 82 mice). Color codes for age. (D) Weighted adjacency matrices displaying average STTC at 1 s lag of P4, P6, P8, P10, and P12 mice as a function of the recording sites in which the spike train pair has been recorded. Color codes for STTC value. In (B) regression coefficients are presented as mean and 95% CI. In (C) data are presented as mean ± SEM. Asterisks in (B) indicate significant regression coefficients of the respective (interaction between) variables for STTC at 1 s lag. Asterisks in (C) indicate significant effect of age*distance interaction. ***p<0.001. Linear mixed-effect models. For detailed statistical results, see Supplementary file 1.

Figure 3—figure supplement 1. The spike time tiling coefficient (STTC) developmental decrease follows specific spatial patterns in the mouse medial prefrontal cortex (mPFC).

(A) Scatter plot displaying the STTC computed in the first half of the recording with respect to STTC computed in the second half of the recording (n=40,921 spike train pairs and 82 mice). (B) Scatter plot displaying Pearson and Spearman correlation coefficient for STTC computed on the first and second half of the recording over lags (n=40,921 spike train pairs and 82 mice). (C) Weighted adjacency matrices displaying average STTC at 2.5 ms lag of P4, P6, P8, P10, and P12 mice as a function of the recording sites in which the spike train pair has been recorded. Color codes for STTC value. For detailed statistical results, see Supplementary file 1.