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. 2021 Jun 4;28(5):453–468. doi: 10.1177/10738584211021018

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — The distribution of Gp1 mGluRs at glutamatergic synapse. Gp1 mGluRs are mostly localized postsynaptically and promote a calcium influx upon their activation and contribute to LTP/LTD induction. mGluR5 also modulates synaptic release probability by depleting PIP2. The astrocytes also express mGluR5.