In Section 3.5 and Table 2, citation of [17] is incorrect and the reference should be to a different paper. These should now read as follows.
3.5. Clinical evidence to date
As randomized trials are ongoing, there is currently no prospective phase III evidence comparing hypofractionated with conventionally fractionated postoperative prostate radiotherapy. Thus, current efficacy is largely based on retrospective analyses (Table 2). Lee et al. [41] retrospectively evaluated men who underwent salvage radiotherapy for biochemical relapse following prostatectomy.
Table 2.
Studies reporting efficacy of hypofractionated radiotherapy for postoperative prostate cancer
| Study | Patients (n) | Total dose (Gy) | Number of fractions | Technique | Median follow-up (mo) | Biochemical recurrence–free survival (%) | DM (%) | OS (%) | Acute gastrointestinal toxicity (≥G3), n | Acute genitourinary toxicity (≥G3), n | Late gastrointestinal Toxicity (≥G3), n | Late genitourinary toxicity (≥G3), n |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lee et al. (2004) [41] | 61 | 50–52.5 | 20 | 3D | 36 | 74 | 0 | 100 | 0 | 0 | 0 | 1 |
| Wong et al. (2008) [31] | 50 | 65–70 | 26–28 | IMRT | 24 | 72.9 | 2 | 96 | 0 | 0 | 0 | 0 |
| Kruser et al. (2011) [32] | 108 | 65 | 26 | IMRT | 32.4 | 67 | 2.7 | 99 | 0 | 1 | 0 | 0 |
| Lewis et al. (2016) [33] | 56 | 57.5–65 | 23–26 | IMRT | 48 | 75 | NR | 96 | 0 | 0 | 2 | 4 |
| Fersino et al. (2017) [34] | 125 | 65.5–71.4 | 28–30 | IMRT | 18 | 85.5 | NR | NR | 0 | 1 | 0 | 2 |
| Macchia et al. (2017) [35] | 124 | 62.5 | 25 | IMRT | 60 | 86.5 | 1 | 100 | 0 | 1 | NR | NR |
| Tandberg et al. (2018) [36] | 167 | 65 | 26 | IMRT | 38.6 | 78.4 | 4 | 94.3 | 0 | 1 | 11 | 1 |
| Picardi et al. (2018) [37]a | 918 | 50–72.8 | 20–29 | 2D, 3D and IMRT | 36 | 74–85 | NR | NR | NR | NR | NR | NR |
| Siepe et al. (2018) [38]a | 1208 | 37.8–74.2 | 21–28 | 3D and IMRT | 60 | 86.5 | NR | NR | 0 | NR | NR | NR |
| Chin et al. (2020) [39] | 112 | 52.5 | 20 | 3D | 120 | 51.5 | 16 | 75 | NR | NR | NR | NR |
2D = two-dimensional volume imaging; 3D = three-dimensional conformal radiotherapy; G3 = grade 3; DM = distant metastases; IMRT = intensity-modulated radiation therapy; n = number of patients; NR = not reported; OS = overall survival.
Systematic review.
Conflicts of interest: The authors have nothing to disclose.
Reference
- 41.Lee L.W., McBain C.A., Swindell R., Wylie J.P., Cowan R.A., Logue J.P. Hypofractionated radiotherapy as salvage for rising prostate-specific antigen after radical prostatectomy. Clin Oncol. 2004;16:517–522. doi: 10.1016/j.clon.2004.07.006. [DOI] [PubMed] [Google Scholar]