Table 4.
Comparison of people with HIV characteristics with a FAST-score greater than 0.35 and at least 0.67.
| FAST score <0.35 (n = 231; 87.8%) | FAST score >0.35 (n = 32; 12.2) | FAST score <0.67 (n = 255; 97%) | FAST score ≥0.67 (n = 8; 3%) | |||
| Variable | n (% or IQR) | n (% or IQR) | P value | n (% or IQR) | n (% or IQR) | P value |
| Age in years | 52 (42–58) | 51.5 (44.3–59.5) | 0.512 | 52 (42–58) | 52 (46.3–59.3) | 0.808 |
| Time since diagnosis (years) | 12 (6–20) | 11 (5–22.5) | 0.790 | 12 (6–20) | 8 (2.5–24) | 0.588 |
| Sex | 0.052 | 0.735 | ||||
| Male | 156 (67.5) | 27 (84.4) | 177 (69.4) | 6 (75) | ||
| Female | 75 (32.5) | 5 (15.6) | 78 (30.6) | 2 (25) | ||
| Metabolic comorbidities | ||||||
| BMI (kg/m2) | 24.7 (22.2–27.7) | 27.8 (25.4–33.7) | <0.001 | 25 (22.3–27.9) | 27.5 (24.5–37.7) | 0.049 |
| Obese (>30 kg/m2) | 31 (13.7) | 10 (33.3) | 0.006 | 38 (15.3) | 3 (50) | 0.050 |
| Waist circumference (cm) | 95 (86; 102) | 104.5 (95.8; 116.5) | <0.001 | 96 (86.8; 103.3) | 104 (100; 133) | 0.009 |
| Male >94 | 86 (55.1) | 22 (81.5) | 0.010 | 102 (57.6) | 6 (100) | 0.038 |
| Female >80 | 64 (85.3) | 4 (80) | 0.746 | 67 (85.9) | 1 (50) | 0.160 |
| Type 2 diabetes | 16 (7.4) | 10 (38.5) | <0.001 | 22 (9.3) | 4 (66.6) | <0.001 |
| High triglycerides | 58 (38.2) | 13 (56.5) | 0.095 | 67 (39.8) | 5 (57.4) | 0.362 |
| High cholesterol | 81 (51.3) | 10 (45.5) | 0.610 | 91 (52.6) | 0 | 0.006 |
| Arterial hypertension | 67 (29.9) | 11 (39.3) | 0.312 | 74 (30.1) | 4 (66.6) | 0.055 |
| Metabolic syndrome | 56 (24.2) | 14 (33.8) | 0.019 | 69 (25.5) | 5 (62.5) | 0.020 |
| Alcohol intake (g/day) | ||||||
| Male | 0.259 | 0.575 | ||||
| Male >20 (g/day) | 16 (11.1) | 1 (3.8) | 16 (9.7) | 1 (16.6) | ||
| Male <20 (g/day) | 129 (89.9) | 25 (96.2) | 149 (89.3) | 5 (83.3) | ||
| Female | 0.296 | 0.739 | ||||
| Female >10 (g/day) | 6 (8.9) | 1 (25) | 7 (10) | 1 (100) | ||
| Female <10 (g/day) | 61 (91.1) | 3 (75) | 63 (90) | 0 | ||
| Laboratory values | ||||||
| ALT (U/l) | 22 (17–29.3) | 50 (36–76.3) | <0.001 | 23 (18–31) | 83.5 (44–127) | <0.001 |
| AST (U/l) | 25 (22–29) | 40 (35–52.3) | <0.001 | 26 (22–31) | 56 (39.5–125.5) | <0.001 |
| Triglycerides (mg/dl) | 129 (86–184.5) | 157 (109–239) | 0.038 | 130.5 (88–189.5) | 177 (100–239) | 0.431 |
| Cholesterol (mg/dl) | 201 (174–226) | 186.5 (172.8–223.3) | 0.735 | 201 (174–226.5) | 177 (173–183) | 0.021 |
| HDL (mg/dl) | 48 (38.5–58.5) | 45.5 (40–51.5) | 0.538 | 48 (39–58) | 44.5 (37.3–45.8) | 0.251 |
| LDL (mg/dl) | 120 (102.5–143) | 124 (92.8–168) | 0.592 | 124 (102.5–144.5) | 102 (90–125.3) | 0.201 |
| HbA1c (%) | 5.4 (5.1–5.7) | 5.9 (5.5–7.2) | 0.004 | 5.4 (5.1–5.7) | 6.9 (5.7–7.8) | 0.024 |
| Uric acid (mg/dl) | 5.5 (4.8–6.3) | 6.1 (5.1–7.2) | 0.123 | 5.5 (4.8–6.4) | 5.2 (4.4–5.5) | 0.294 |
| HIV-related parameters | ||||||
| HIV RNA at inclusion | 0.547 | 0.633 | ||||
| Above threshold | 87 (37.8) | 10 (32.3) | 95 (37.4) | 2 (28.6) | ||
| Below threshold | 143 (62.2) | 21 (67.7) | 159 (62.6) | 5 (71.4) | ||
| CD4 (cells/μl) | 724 (516–905) | 764 (549.3–991.5) | 0.439 | 724.5 (516.8–910.8) | 816 (669–1193) | 0.265 |
| >500 CD4+ cells/μl | 174 (75.3) | 24 (75) | 0.968 | 192 (75.3) | 6 (75) | 0.985 |
| CDC C | 46 (31.3) | 6 (23.1) | 0.400 | 51 (30.7) | 1 (14.3) | 0.353 |
| NRTI (TAF vs. TDF) | 0.299 | 0.016 | ||||
| TAF | 150 (85.7) | 17 (77.3) | 164 (85.9) | 3 (50) | ||
| TDF | 25 (14.3) | 5 (22.7) | 27 (14.1) | 3 (50) | ||
| INSTI | 157 (68.5) | 17 (58.6) | 0.282 | 169 (67.3) | 5 (71.4) | 0.819 |
| TAF and INSTI | 106 (77.9) | 9 (56.3) | 0.056 | 113 (76.4) | 2 (50) | 0.226 |
Data are expressed as numbers, median, percentage (%) or interquartile ranges (IQR 25th–75th). ALT, alanine-aminotransaminase; AST, aspartate-aminotransaminase; HDL, high-density lipoprotein; INSTI, integrase inhibitors; LDL, low-density lipoprotein; NRTI, nucleoside reverse transcriptase inhibitors; TAF, tenofovir alafenamide; TDF, tenofovir disoproxil fumarate. Mann–Whitney U test and chi-square test were used to compare continuous and categorical values, respectively. Boldface indicates statistical significance. A P value less than 0.05 was considered statistically significant.