Table 1.

A summary of different LPS administration regimens among studies utilizing LPS-induced neuroinflammation model.

Route and Period of LPS Administration	Dose	Species	Type of LPS	Performed Behavioral Tests	Reference
intraperitoneal, 7 days	500 and 750 μg/kg	mice	N/A	MWM, PAT, PT	[1]
intraperitoneal, 7 days	250, 500 and 750 μg/kg	mice	E. coli O111:B4	NOR, NAD, OFT	[14]
intraperitoneal, 5 days	1 mg/kg	mice	E. coli O26:B6 *	MWM	[70]
intraperitoneal, 7 days	250 μg/kg	mice	E. coli O55:B5	MWM, Y-maze test	[71]
intraperitoneal, 7 days	250 μg/kg	mice	E. coli O111:B4	NOR, MWM	[23]
intraperitoneal, 7 days	250 μg/kg	mice	E. coli O127:B8	Y-maze test, NOR, ST, OFT	[77]
intraperitoneal, single dose	5 mg/kg	mice	E. coli O26:B6 *	OFT, PT	[70]
intracebro- ventricular, single dose	12 μg	mice	N/A	MWM, PAT, PT	[1]
intranigral, single dose	5 μg	rats	E. coli O111:B4	amphetamine- induced rotation test	[78]
intrastriatal, single dose	10 µg	mice	N/A	rotarod test, buried food-seeking test, OFT	[76]
intranasal, 6 weeks	10 µg	mice	E. coli O55:B5	OFT, PT, olfactory function test	[79]

* In the study by Yang and colleagues, LPS from E. coli O26:B6 is mentioned as a material in the cell culture treatment; however, this information is not provided in the animal model-so it is hypothesized that the same LPS type has been used [70]. Abbreviations: N/A—no data available; LPS—lipopolysaccharide; MWM—Morris water maze test; PAT—passive avoidance test; PT—pole test; OFT—open field test; NOR—novel object recognition test; NAD—novel arm discrimination task; ST—splash test.