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. 2022 Sep 7;13(3):19476035221121792. doi: 10.1177/19476035221121792

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Dimorphic enrichment of ECM proteins in male and female cartilage. (A) Pathway analysis of protein abundances in male and female cartilage. (B) Heat map with ECM proteins showing a significant difference in male and female cartilage. Upregulation is shown in red and downregulation is shown in green. Fold change of male compared with female is indicated in parenthesis; n = 6♂ + 6♀. (C) Summary schematics of main protein functions enriched in female and male cartilage. Male cartilage was enriched in ECM connectors and crosslink proteins, whereas female cartilage was enriched in PCM proteins and cell matrix adhesion regulators. A-B: Empirical Bayes moderated t test implemented in limma. ECM = extracellular matrix; FDR = False Discovery Rate; PCM = pericellular matrix; NCAM1 = neural cell adhesion molecule 1.