Tab. 2:

Criteria of the GRADE EtD framework

Criteria
Problem	Is the problem a priority?
Desirable and undesirable effects	How substantial are the desirable/undesirable anticipated effects?
Certainty	What is the overall certainty of the evidence of effects?
Values	Is there important uncertainty about or variability in how much people value the main outcomes?
Balance	Does the balance between desirable and undesirable effects favor the option or the comparison?
Resource use	How large are the resource requirements (costs)? What is the certainty of the evidence of resource requirements? Does the cost effectiveness of the option favor the option or the comparison?
Equity	What would be the impact on health equities?
Acceptability	Is the option acceptable to key stakeholders?
Feasibility	Is the option feasible to implement?