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. 2022 Aug 2;609(7927):611–615. doi: 10.1038/s41586-022-05143-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, Structural comparisons between the apo and IAA-bound structure of PIN1. b, Residues surrounding the IAA binding site remain almost identical in the apo and IAA-bound structures. c, Structural comparisons between the apo and NPA-bound structure of PIN1. d, Residues surrounding the NPA binding site undergo subtle rearrangements. e, Chemical structures of IAA and NPA. f, Superposition of the IAA-bound and NPA-bound structures of PIN1. g, The benzoic group of NPA binds to a pocket formed by TM5 and the crossover regions of TM4 and TM9. Surface electrostatic potential is shown for PIN1.