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. 2022 Aug 2;609(7927):611–615. doi: 10.1038/s41586-022-05143-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Side view and section view of the surface electrostatic potential of PIN1 in the apo state. Negative and positive charges are coloured red and blue, respectively. b, Overview of the surface electrostatic potential of the PIN1 monomer from the intracellular side. The cavity is indicated with yellow dashed lines. c, Coordination of IAA by PIN1. IAA is shown as spheres in the overall view (left). TM1, TM2 and TM7 are coloured yellow; TM6 is coloured grey and transmembrane segments of the transporter domain are coloured marine blue. The IAA molecule and interacting residues are shown as sticks in the magnified views (centre and right). Hydrogen bonds are shown in red dashed lines. d, Coordination of NPA by PIN1. NPA is shown in spheres and sticks in the side view (left) and magnified views (centre and right), respectively.