Figure 2.

Summary of the effects of chemotherapy and targeted therapy on the tumor microenvironment in NS-NSCLC, breast cancer, pancreatic cancer, colorectal cancer, hepatocellular carcinoma and melanoma Chemotherapies and targeted therapies are separated in each situation. Treatments that modulate upwards are represented in green, and those that modulate downwards are represented in red. NS-NSCLC: Non squamous non-small cell carcinoma, HCC: Hepatocellular carcinoma, CRC: Colorectal cancer, Treg: regulatory T celsl, MDSC: myeloid-derived suppressor cell, TAM2: tumor associated macrophages of phenotype 2, CAF: cancer associated fibroblast, MAF: Melanoma associated fibroblast, CD8: CD8 T cell, i: inhibitor, a: agonist, 5-FU: 5-Fluorouracil. (Made with Biorender).