Immune checkpoint inhibitors (ICIs) |
Tumor microenvironment (TME) |
Regulatory T lymphocytes (Treg) |
Myeloid-derived suppressor cells (MDSCs) |
Tumor-associated macrophages (TAMs) |
Chemotherapies (CT) |
Targeted Therapies (TT) |
Tyrosine Kinase Inhibitor (TKI) |
Monoclonal antibodies (mAb) |
Immunogenic cell death (ICD) |
High-Mobility Group Box 1 (HMGB1) |
Natural Killer (NK) |
Dendritic cells (DCs) |
Cancer Associated Fibroblast (CAF) |
Indoleamine 2,3-DiOxygenase (IDO) |
Inducible Nitric Oxide Synthase (iNOS) |
Arginase 1 (Arg1) |
Cyclo-oxygenase (COX) |
Prostaglandin E2 (PGE2) |
Signal Transducer and Activator of Transcription 3 (STAT3) |
Vascular Endothelial Growth Factor A (VEGF-A) |
Programmed cell Death-Ligand 1 (PD-L1) |
Programmed cell Death protein 1 (PD-1) |
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) |
T-cell immunoglobulin and immunoreceptor Tyrosine-based inhibitory domain (TIGIT) |
Non-Squamous-Non-Small Cell Lung Cancer (NS-NSCLC) |
Breast Cancer (BC) |
HepatoCarcinoma Cancer (HCC) |
ColoRectal Cancer (CCR) |
Peripheral Blood Mononuclear Cells (PBMCs) |
Cytotoxic T lymphocyte (CTL) |
Immunoglobulin-like transcript 4 (ILT4) |
Retinoid X receptor (RXR) |
Cisplatin-Pemetrexed (CP) |
Optineurin (OPTN) |
Janus kinase 1/2 (JAK 1/2) |
Tumor-infiltrating lymphocytes (TILs) |
Breast Cancer (BC) |
Triple-negative breast cancer (TNBC) |
Hormone-receptor breast cancer (HR+BC) |
Human Epidermal Growth Factor Receptor-2 (HER-2) |
Antibody-drug-conjugates (ADC) |
Cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) |
Poly (ADP-ribose) polymerase (PARP) |
Colony-stimulating factor 1 receptor axis (CSF1/CSF1R) |
Interferon (IFN) |
Antibody-dependent cell-mediated cytotoxicity (ADCC) |
Temporary Use Authorization (ATU) |
Phosphodiesterase type 5 (PDE5) |
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) |
Chemokine Receptor type 4 (CXCR4) |
C-Chemokine receptor type 2 (CCR2) |
Microsatellite-instable (MSI+) |
Protein tyrosine phosphatase-2 (SHP2) |
C-C chemokine receptor type 5 (CCR5) |
Mouse Double Minute 2 (MDM2) |
Yes‐associated protein 1 (YAP1) |