Progression of serostatus during the course of the Covid-19 pandemic in South Africa, and estimated thresholds of protection against seroconversion. A. Daily reported cases in South Africa from September 2020 to March 2022, coloured by predominant circulating serotype, from https://covid19.who.int/WHO-COVID-19-global-data.csv. B. Individual level S-ancestral (WT) IgG titres over time, coloured by vaccine status prior to sampling. C. Wave specific change in S-ancestral (WT) IgG titres over the course of the beta, delta, and omicron waves coloured by whether antibody levels declined between samples, with estimated median and 95% CrI threshold (dot and whisker) indicating 50% protection from seroconversion.