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. 2021 Oct 25;17(9):1020–1039. doi: 10.1080/15592294.2021.1982158

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 9. — Gene regulatory network in cardiac fibroblasts.

(a) Top 500 most differentially expressed genes (cyan dots) among cardiac fibroblasts in different states with at least one of the 7 motifs (Fosl1, Rora, Stat1, Nf1, Tead2, Runx1, and Tcf21; blue circles) identified in the ATAC-seq peaks ± 100 kb of their TSSs were selected for gene regulatory network (GRN) construction. Red lines indicate positive regulation. Green lines indicate negative regulation. (b) Possible functions of TFs based on GO enrichment analysis of genes positively or negatively regulated by individual TFs. Red arrows indicate positive regulation. Black arrows indicate negative regulation.