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. Author manuscript; available in PMC: 2023 Sep 15.
Published in final edited form as: Cell. 2022 Sep 15;185(19):3533–3550.e27. doi: 10.1016/j.cell.2022.08.008

FIGURE 4. Stabilization of the water between the MIDAS metal ion and Ser-123 sidechain by closing antagonists.

FIGURE 4.

(A-F) The environment around the indicated compound substructures near the MIDAS metal ion, waters, and Ser-123 is shown after superposition on the βI domain. 2Fo-Fc electron density (cyan mesh) is contoured around atoms at 1.5 σ. Colors are as in Fig. 2 including Mg2+ and Mn2+ ions as gold and purple spheres, respectively, and waters as smaller red spheres. Black dashes represent coordination and hydrogen bonds.