Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Transcription-coupled DNA damage and mutation rates. Unwound DNA structures during transcription are susceptible to environmental stress, creating transcription-coupled damage (TCD). TCDs in genes with a normal transcription level are repaired through transcription-coupled repair mechanisms, while some TCDs in highly transcribed genes or inactive are not repaired, increasing their mutation rates [109].
