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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 2022 Sep 2;119(38):e2213287119. doi: 10.1073/pnas.2213287119

Retraction for Yuan et al., Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis

PMCID: PMC9499498  PMID: 36053740

Medical Sciences Retraction for “Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis,” by Guoxiang Yuan, Ying-Jie Peng, Vaddi Damodara Reddy, Vladislav V. Makarenko, Jayasri Nanduri, Shakil A. Khan, Joseph A. Garcia, Ganesh K. Kumar, Gregg L. Semenza, and Nanduri R. Prabhakar, which was first published April 22, 2013; 10.1073/pnas.1305961110 (Proc. Natl. Acad. Sci. U.S.A. 110, E1788–E1796).

The authors note, “We are retracting this article due to concerns with Figure 5. In Figure 5A, there is a concern that the first and second lanes of the HIF-2α panel show the same data, and that the first and second lanes of the HIF-1α panel show the same data, despite all being labeled as unique data. In Figure 5D, there is a concern that the second and third lanes of the HIF-1β panel show the same data despite being labeled as unique data. We believe that the overall conclusions of the paper remain valid, but we are retracting the work due to these underlying concerns about the figure. Confirmatory experimentation has now been performed and the results can be found in a preprint article posted on bioRxiv, ‘Homeostatic responses to hypoxia by the carotid body and adrenal medulla are based on mutual antagonism between HIF-1α and HIF-2α’ (https://doi.org/10.1101/2022.07.11.499380). We apologize for the inconvenience.”


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