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. 2022 Aug 30;14(9):1927. doi: 10.3390/v14091927

Figure 2.

Figure 2

Both huNRG and huDRAG-A2 mice can sustain HIV infection, and both display a drop in CD4+ T cells 8 weeks post infection. Viral load in the (A) blood plasma and (B) vaginal wash of huNRG (N = 5) and huDRAG-A2 (N = 3) mice at 2, 4, 6 and 8 weeks post-intravaginal HIV infection; (C) percent and (D) absolute human CD4+ T cell frequency pre- and 8 weeks post-infection in the blood of huNRG (N = 5) and huDRAG-A2 (N = 3). No significant differences were observed in CD4+ T cell depletion between the huNRG and huDRAG-A2 groups. Data for huNRG and huDRAG-A2 are combined from 2 separate experiments and are expressed as mean +/− SEM, n.s = not significant, p value = * <0.05, ** <0.01, *** <0.001. Dotted line indicates the threshold of detection of 1500 HIV-1 RNA copies/mL.