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. 2022 Aug 28;10(9):502. doi: 10.3390/toxics10090502

Table 5.

Estimated BMDs and BMDLs for BTX components based on their hematological effects.

BTX Component Model Name Chi-Squared p for Goodness-of-Fit Tests AIC BMD
(mg/m3 × year)
BMDL
(mg/m3 × year)
Benzene Multistage a 6.017 0.421 777.588 2.138 1.559
Toluene Dichotomous Hill b 4.322 0.364 704.276 1.449 1.325
Xylene Probit c 5.669 0.461 741.547 2.937 2.312

Note: Abbreviations: AIC, Akaike’s Information Criterion; BMD, benchmark dose; BMDL, lower confidence limit of BMD. a The Multistage dose–response model was represented as P[X] = background + (1 − background) × [1 − exp(−slope1 × X1 − slope2 × X2−…)]. b The Dichotomous Hill dose–response model was defined by P[X] = background + (v − v × background)/[1 + exp(−intercept − slope × Log(X))], where v is the maximum probability of response predicted by the model. c The Probit dose–response model was represented as P[X] = CumNorm(intercept + slope × X).