Table 7.
Effect of Rumex hastatus crude extract (Rh.Cr) and fractions: n-hexane (Rh.n-Hex), ethyl acetate (Rh.ETAC), aqueous (Rh.Aq), rutin and omeprazole against an ethanol-induced ulcer in rats.
| Treatment (mg/kg) | Ulcer Index | % Inhibition |
|---|---|---|
| Saline (10 mL/kg) | 0 ± 0.0 | - |
| Ethanol (1 mL/100 g) | 10 ± 0.3 ### | 0 |
| Rh.Cr (50 mg/kg) + Ethanol (1 mL/100 g) | 7.0 ± 0.31 *** | 30 |
| Rh.Cr (100 mg/kg) + Ethanol (1 mL/100 g) | 1.5 ± 0.2 *** | 87 |
| Rh.Cr (300 mg/kg) + Ethanol (1 mL/100 g) | 0.6 ± 0.24 *** | 92 |
| Rh.n-Hex (50 mg/kg) + Ethanol (1 mL/100 g) | 5.5 ± 0.05 *** | 47 |
| Rh.n-Hex (100 mg/kg) + Ethanol (1 mL/100 g) | 2.4 ± 0.20 *** | 76 |
| Rh.n-Hex (300 mg/kg) + Ethanol (1 mL/100 g) | 0 ± 0.0 *** | 100 |
| Rh.ETAC (50 mg/kg) + Ethanol (1 mL/100 g) | 6.5 ± 0.25 *** | 35 |
| Rh.ETAC (100 mg/kg) + Ethanol (1 mL/100 g) | 4.8 ± 0.24 *** | 52 |
| Rh.ETAC (300 mg/kg) + Ethanol (1 mL/100 g) | 2.8 ± 0.07 *** | 72 |
| Rh.Aq (50 mg/kg) + Ethanol (1 mL/100 g) | 9.8 ± 0.1 | 2 |
| Rh.Aq (100 mg/kg) + Ethanol (1 mL/100 g) | 10 ± 0.2 | 1.96 |
| Rh.Aq (300 mg/kg) + Ethanol (1 mL/100 g) | 9.6 ± 0.24 | 5.88 |
| Rutin (50 mg/kg) + Ethanol (1 mL/100 g) | 4.52 ± 0.14 *** | 56.8 |
| Rutin (100 mg/kg) + Ethanol (1 mL/100 g) | 2.86 ± 0.02 *** | 73.4 |
| Rutin (200 mg/kg) + Ethanol (1 mL/100 g) | 1.26 ± 0.12 *** | 89.4 |
| Omeprazole (20 mg/kg) + Ethanol (1 mL/100 g) | 0.4 ± 0.04 *** | 96.2 |
Values expressed as mean ± SEM (n = 5). One-way ANOVA with post-hoc Tukey’s test ### p < 0.001 vs. saline group, *** p < 0.001 vs. ethanol group.