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Effects of HEP-1 in RAW264.7/Caco-2 cells model. (A) IL-6. (B) IFN-γ. (C) IL-10. (D) TNF-α. After the treatment of inhibitors including BAY11-7082, SB203580, SP600126, PD98095 and LY294002, the release of (E) NO and (F) TNF-α in NF-κB, MAPK and PI3K/Akt signaling pathways were detected. Data are presented as mean ± SD (n = 3). * p < 0.05, ** p < 0.01 compared with the CK group.
