Table 2.

Results of the Pathway Analysis of Metabolic Biomarkers.

Pathway Name	Match	p	FDR	Impact	Match Details
Plasma
Arginine biosynthesis	7/14	<0.0001	0.0003	0.6244	L-Glutamate; L-Arginine; L-Citrulline; L-Aspartate; Carbamoyl phosphate; L-Glutamine; Fumarate
Aminoacyl-tRNA biosynthesis	11/48	<0.0001	0.0014	<0.0001	L-Phenylalanine; L-Arginine; L-Glutamine; L-Aspartate; L-Methionine; L-Valine; L-Lysine; L-Tryptophan; L-Tyrosine; L-Proline; L-Glutamate
AH
Aminoacyl-tRNA biosynthesis	10/48	<0.0001	0.0001	0.1667	L-Phenylalanine; L-Glutamine; L-Serine; L-Methionine; L-Lysine; L-Leucine; L-Tryptophan; L-Tyrosine; L-Proline; L-Glutamate
Glyoxylate and dicarboxylate metabolism	6/32	0.0003	0.0118	0.1455	cis-Aconitate; L-Serine; L-Glutamate; D-Glycerate; Isocitrate; L-Glutamine
Vitreous
Aminoacyl-tRNA biosynthesis	9/48	<0.0001	0.0005	<0.0001	L-Phenylalanine; L-Glutamine; Glycine; L-Valine; L-Alanine; L-Lysine; L-Leucine; L-Threonine; L-Proline
Alanine, aspartate and glutamate metabolism	7/28	<0.0001	0.0005	0.2484	N-Acetyl-L-aspartate; L-Alanine; L-Glutamine; 2-Oxoglutaramate; Pyruvate; Succinate; 2-Oxoglutarate
Arginine biosynthesis	5/14	<0.0001	0.0009	0.2893	L-Citrulline; L-Ornithine; L-Glutamine; 2-Oxoglutarate; N-Acetyl-L-glutamate
Glycine, serine and threonine metabolism	7/33	<0.0001	0.0009	0.3426	N, N-Dimethylglycine; L-Cystathionine; Glycine; L-Threonine; D-Glycerate; Creatine; Pyruvate
Valine, leucine and isoleucine biosynthesis	3/8	0.0014	0.0235	<0.0001	L-Threonine; L-Leucine; L-Valine
Glyoxylate and dicarboxylate metabolism	5/32	0.0025	0.0346	0.1852	Glycine; D-Glycerate; Acetate; Pyruvate; L-Glutamine

AH = aqueous humor; FDR = false discovery rate.