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. 2022 Sep 2;14(9):1856. doi: 10.3390/pharmaceutics14091856

Figure 5.

Figure 5

Projection of dominant metastates extracted from MSMs onto the GPR97 conformational landscape of BCM–GPR97 (A), BCM–GPR97–Go (B), BCM–GPR97–palmitoylated Go (C), cortisol–GPR97 (D), cortisol–GPR97–Go (E), and cortisol–GPR97–palmitoylated Go (F) systems generated using PCA. The representative GPR97 structure substates in BCM–GPR97 (M1, M2, and M3), BCM–GPR97–Go (M1′, M2′, and M3′), BCM–GPR97–palmitoylated Go (M1″, M2″, and M3″), cortisol–GPR97 (S1, S2, and S3), cortisol–GPR97–Go (S1′, S2′, and S3′), and cortisol–GPR97–palmitoylated Go (S1″, S2″, and S3″), along with their probabilities, are shown, with the TM5, TM6, and TM7 regions colored red, green, and purple, respectively.