Table 3.
Physicochemical characteristics of liposomes based on PC modified by IA-16 loaded with 2-PAM at various surfactant/lipid molar ratios and different loadings of the substrate: encapsulation efficiency (EE, %), loading capacity (LC, %); hydrodynamic diameter (DH, nm), polydispersity index (PdI), and zeta potential (ζ, mV), 25 °C.
| 2-PAM | |||||||
|---|---|---|---|---|---|---|---|
| System | Surfactant/PC Molar Ratio | Initial Concentration of Substrate, mg/mL | EE, % | LC, % | DH, nm | PdI | ζ, mV |
| PC | - | 34 ± 1 | 105 ± 2 | 0.055 ± 0.002 | −3 ± 1 | ||
| IA-16/PC | 0.02/1 | 10 | 74 ± 1 | 48 ± 1 | 122 ± 1 | 0.110 ± 0.018 | 33 ± 1 |
| IA-16/PC | 0.029/1 | 10 | 72 ± 1 | 46 ± 1 | 109 ± 2 | 0.088 ± 0.030 | 42 ± 1 |
| IA-16/PC | 0.04/1 | 10 | 72 ± 1 | 46 ± 1 | 112 ± 2 | 0.082 ± 0.008 | 49 ± 1 |
| IA-16/PC | 0.02/1 | 20 | 73 ± 1 | 96 ± 1 | 131 ± 2 | 0.088 ± 0.024 | 17 ± 1 |
| IA-16/PC | 0.029/1 | 20 | 73 ± 1 | 96 ± 1 | 127 ± 1 | 0.075 ± 0.016 | 23 ± 1 |
| IA-16/PC | 0.04/1 | 20 | 74 ± 1 | 97 ± 1 | 131 ± 1 | 0.080 ± 0.025 | 28 ± 1 |