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. Author manuscript; available in PMC: 2022 Sep 24.
Published in final edited form as: Cancer. 2021 Apr 27;127(17):3246–3253. doi: 10.1002/cncr.33603

TABLE 2.

Differences in Symptom Occurrence and Severity Scores Between the Loneliness Groups

Total Sample (n = 606)
Nonlonely (47.0% [n = 285])
Lonely (53.0% [n = 321])
Characteristica % (No.) % (No.) % (No.) Statistics

Symptom occurrence rates
Depressive symptoms 41.3 (250) 15.8 (45) 64.1 (205) FE, P < .001
Trait anxiety 58.7 (355) 32.6 (93) 81.9 (262) FE, P < .001
State anxiety 48.5 (292) 26.5 (75) 68.0 (217) FE, P < .001
Sleep disturbance 61.8 (373) 46.7 (133) 75.2 (240) FE, P < .001
Morning fatigue 51.5 (311) 34.7 (99) 66.5 (212) FE, P < .001
Evening fatigue 49.0 (296) 35.9 (102) 60.6 (194) FE, P < .001
Decrements in morning energy 69.3 (417) 54.9 (156) 82.1 (261) FE, P < .001
Decrements in evening energy 67.2 (406) 60.7 (173) 73.0 (233) FE, P = .001
Decrements in cognitive function 64.7 (391) 45.4 (129) 81.9 (262) FE, P < .001
Pain 64.5 (386) 59.7 (166) 68.8 (220) FE, P = .026
Symptom severity scores
Mean (SD) Mean (SD) Mean (SD)
Center for Epidemiological Studies–Depression (≥16) 14.8 (10.4) 8.7 (6.8) 20.2 (10.1) t = −16.48, P < .001
Trait anxiety (≥31.8) 36.3 (11.3) 29.6 (7.0) 42.3 (11.0) t = −17.16, P < .001
State anxiety (≥32.2) 34.9 (13.2) 28.4 (9.5) 40.7 (13.2) t = −13.18, P < .001
General Sleep Disturbance Scale (≥43.0) 50.7 (20.7) 42.8 (19.0) 57.8 (19.6) t = −9.50, P < .001
Morning fatigue (≥3.2) 3.5 (2.5) 2.6 (2.2) 4.3 (2.5) t = −9.06, P < .001
Evening fatigue (≥5.6) 5.3 (2.1) 4.7 (2.1) 5.8 (2.0) t = −6.39, P < .030
Morning energy (≤6.2) 4.8 (2.5) 5.7 (2.4) 4.1 (2.2) t = 8.26, P < .001
Evening energy (≤3.5) 2.9 (2.0) 3.2 (2.2) 2.6 (1.8) t = 3.47, P = .001
Attentional Function Index (<5 = low cognitive function,
5–7.5 = moderate cognitive function, >7.5 = high cognitive function)
6.7 (1.9) 7.5 (1.5) 5.9 (1.8) t = 11.91, P < .001
Worst pain intensity score 6.5 (2.2) 6.2 (2.1) 6.7 (2.2) t = −2.28, P = .023
Mean pain interference score 3.4 (2.3) 2.6 (2.0) 4.0 (2.3) t = −6.08, P < .001

Abbreviation: SD, standard deviation.

a

Clinically meaningful cutoff scores are in parentheses.