Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
| Clinical evidence | Macroscopic anomalies | Microscopic anomalies | |
| Grade 0 | Present | No | No |
| Grade 1 | + | No | Moderate fibrillary astrocytosis |
| Grade 2 | + | + caudate/putamen; - globus pallidus | + |
| Grade 3 | + | The lateral segment of globus pallidus (fibrillary astrocytosis) | + |
| Grade 4 | + | Shrunken caudate and small nucleus accumbens | + |
