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. 2022 Sep 26;84:104280. doi: 10.1016/j.ebiom.2022.104280

Figure 3.

Figure 3

Adjacent ratios in patients with neuroinflammatory control group (n=12), other non-inflammatory neurological controls (OND, n=29), other seizures (n=26) and epileptic (epileptic) spasms (n=34). The primary group of interest was the epileptic spasms group, so pairwise comparisons with Mann Whitney U test were performed between the epileptic spasms group and the 3 control groups, and are presented in supplementary table 7. Only statistically significant findings after Bonferroni correction are presented in the figure. A decrease of the KYNA/KYN ratio was observed in the epileptic spasms group compared to OND controls (p=0.0002) (Mann Whitney U test) (Figure 3a). As expected, the KYN/TRP ratio was higher in the neuroinflammatory group compared to the epileptic spasms group (p=0.0001) (Mann Whitney U test) (Figure 3b). Asterisks above the horizontal lines of the groups indicate significant difference: *p=0.0002 and **p=0.0001.