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. 2022 Mar 31;107(10):2395–2407. doi: 10.3324/haematol.2021.280169

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Copyright© 2022 Ferrata Storti Foundation

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Figure 3. — Phenotypic characterization of BCMA-CAR transduced T cells. (A) CD4/CD8 ratio of different anti-BCMA chimeras. CAR-transduced T cells or control T cells were stained with anti-CD4 and CD8 antibodies and analyzed by flow cytometry on day 7. These results are representative of 4 independent experiments with different donors. No significant difference was observed between the different groups. (B) Memory phenotype of T cells transduced with different BCMA chimeras. Three weeks following transduction, CAR-transduced T cells or control T cells were stained with anti-CD45RO and CCR7 antibodies and analyzed by flow cytometry. These results are representative of the mean of 4 independent experiments with different donors (n=4). (C) BCMA-CAR T cells in culture were monitored for the expression of exhaustion markers PD-1, LAG-3, TIM-3 and TIGIT over time (as indicated). BCMA: B-cell maturation antigen; CAR: chimeric antigen receptor.