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. 2022 Sep 22;8(9):e10737. doi: 10.1016/j.heliyon.2022.e10737

Figure 6.

Figure 6

Effect of turmeric extract on the apoptotic and inflammatory signals in the liver tissue obtained from alcohol-induced SD rats. (a) Immunoblotting of Bax, Bcl-2, and β-actin. (b) Immunoblotting of Cyt C and VDAC in the mitochondria and cytoplasm. Observations depict the movement of Cyt C and VDAC. The mitochondria and cytoplasm were fractionated using liver tissue lysates. Observations confirm that VDAC is expressed only in the mitochondria. (c) Immunoblotting of the cleavage of caspase 3. (d–f) mRNA expression of inflammatory mediators (IL-1β, IL-6, and TNF-α) in the liver tissue. Data are shown as mean ± SEM (n = 8). p < 0.05 (#) represent differences from the EtOH treated group. Full and non-adjusted images of immunoblots were shown in the supplementary material (Supplementary Figure 2). Cyt C, cytochrome C; EtOH; ethanol; VDAC, voltage-dependent anion channel; IL, interleukin; TNF, tumor necrosis factor.