Schematic representation demonstrating the influence of turmeric extract on the liver of rodents administered with a single high dose of alcohol. Administration of turmeric extract enhances ADH, ALDH, catalase, SOD, and GPx activity, positively influencing hangover symptoms. In addition, administration of turmeric extract reduced ethanol-induced increase in the CYP2E1 mRNA expression and enzyme activity, ROS generation, and apoptotic and inflammatory signals.