. Author manuscript; available in PMC: 2023 Oct 1.

Published in final edited form as: Cancer. 2022 Aug 10;128(20):3602–3609. doi: 10.1002/cncr.34426

Table 2.

Age Adjusted Linear Regression Estimates for Ki67 and Oncotype RS regressed on tumor characteristics

Tumor Characteristics	Ki67			Oncotype RS
Tumor Characteristics	Geometric Mean^a	Ratio of Geometric Means^a/Slope^b,c [95% CI]	P-value	Geometric Mean^a	Ratio of Geometric Means^a/Slope^b,c [95% CI]	P-value
Poorly Differentiated Tumor ^a
No	8.16	Reference		13.84	Reference
Yes	27.90	3.42 [2.86, 4.08]	<0.0001^*	19.39	1.40 [1.24, 1.58]	<0.0001^*
Nodal Status ^a
Negative	10.96	Reference		14.95	Reference
Positive	16.59	1.51 [1.13, 2.03]	0.0059^*	17.58	1.18 [0.99, 1.40]	0.0686
Tumor Size ^b		0.42% [0.26%, 0.58%]	<0.0001^*		0.02% [−0.08%, 0.12%]	0.6952
PR% ^c		−0.11% [−0.37%, 0.14%]	0.3937		−0.71% [−0.85%, −0.58%]	<0.0001^*
ER% ^c		−1.40% [−2.31%, −0.49%]	0.0028^*		−1.31% [1.84%, −0.78%]	<0.0001^*

Geometric Mean presented within each level of categorical variables with Ratios of Geometric Means.

Slope presented for continuous variables; percent change (negative-reduction; positive-increase) in risk score per 1% increase in tumor size.

Slope presented for continuous variables; percent change (negative-reduction; positive-increase) in risk score per 1 unit increase in PR%, ER%.

P<0.05; CI: Confidence Interval