Duplicates removed	10
Excluded during initial screening (e.g. press releases; news reports; not relevant drug/indication; preclinical study; reviews; case reports; not randomized trial)	0
Excluded during writing (e.g. reviews; duplicate data; small patient number; nonrandomized/phase I/II trials)	12
Cited efficacy/tolerability articles	6
Cited articles not efficacy/tolerability	29
Search Strategy: EMBASE, MEDLINE and PubMed from 1946 to present. Clinical trial registries/databases and websites were also searched for relevant data. Key words were varenicline, OC-01, Tyrvaya, intranasal, dry eye disease, DED, keratitis sicca. Records were limited to those in English language. Searches last updated 19 Sep 2022.