Fig. 1.

A graphical overview of extra cellular matrix (ECM) and its major components. ECM is classified into 2 major types that are basement membrane (BM) and interstitial space (IS), BM is found between epithelial cells and connective tissues. BM is composed of collagen IV meshwork that attaches with ECM components like laminins, perlecan, and minor collagens. IS is made up of collagen fibrils, secreted proteoglycans (PGs), matricellular proteins, and hyaluronan. This unique connection produces a dynamic framework for cells to adhere to ECM using surface proteins, such as cell surface PGs, integrins, glypicans and, syndecan. The signal transduction takes place by these interactions which control the various functions. GFR, growth factor receptor.