Fig. 2.

Schematic representation of different extra cellular matrix remodeling targets and applied approaches for therapeutics. (a) Axonal guidance, which stimulates axonal sprouting, requires molecular signaling. (b) The intrinsic remyelination could be promoted. (c) Stem cells from the central canal could be mobilized or induced for regeneration. (d) Regeneration of neurons with the help of different growth factors. (e) The genetically modified cells factor expression is one of the approaches to increase neuronal survival and migration. (f) Different biomaterials are used as a scaffold that maintains structural integrity and promotes regeneration. (g) Glial scar limits axonal regeneration which can be degraded by chondroitinase ABC. (h) The regeneration and plasticity of new neuronal connections could be an approach.