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. Author manuscript; available in PMC: 2023 Jul 21.
Published in final edited form as: Cell. 2022 Jul 13;185(15):2770–2788. doi: 10.1016/j.cell.2022.06.035

Figure 2: Immunosuppression in the Tumor Immune Microenvironment (TIME).

Figure 2:

The TIME is made up of malignant cells, stomal cells and immune cells, all of which can suppress tumor directed immunity by acting directly or indirectly on effector T cells (Teff). Boxes depict select immunosuppressive mechanisms employed by these various cell types: cancer cells (Ca), regulatory T cells (Treg), dendritic cells (DC), macrophages (MΦ) and myeloid derived suppressor cells (MDSC; (Veglia et al., 2018)), and cancer associated fibroblasts (CAF).